解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Maternal undernutrition is known to adversely impact fetal health and development. Insults experienced in utero alter development of the fetus as it adapts to microenvironment stressors, leading to growth restriction and subsequent low birth weight. Infants born small for gestational age have significantly increased r...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174416000106
更新日期:2016-10-01 00:00:00
abstract::The evidence underpinning the developmental origins of health and disease (DOHaD) is overwhelming. As the emphasis shifts more towards interventions and the translational strategies for disease prevention, it is important to capitalize on collaboration and knowledge sharing to maximize opportunities for discovery and ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174416000167
更新日期:2016-10-01 00:00:00
abstract::Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174416000118
更新日期:2016-08-01 00:00:00
abstract::Androgens may directly modulate early ovarian follicular development in preantral stages and androgen excess before puberty may disrupt this physiological process. Therefore, the aim of this study was to investigate the dynamics of follicular morphology and circulating androgen and estradiol levels in prepubertal Wist...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174416000222
更新日期:2016-08-01 00:00:00
abstract::An estimated 200 million children worldwide fail to meet their development potential due to poverty, poor health and unstimulating environments. Missing developmental milestones has lasting effects on adult human capital. Africa has a large burden of risk factors for poor child development. The objective of this paper...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001427
更新日期:2016-04-01 00:00:00
abstract::Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovas...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415007953
更新日期:2016-04-01 00:00:00
abstract::Early patterns of gut colonization may predispose children to adult disease. Exposures in utero and during delivery are associated with the infant gut microbiome. Although ~35% of women carry group B strep (GBS; Streptococcus agalactiae) during pregnancy, it is unknown if GBS presence influences the infant gut microbi...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001361
更新日期:2016-02-01 00:00:00
abstract::Breast milk constitutes one of the most important sources of postnatal microbes. However, the influence of perinatal factors on the milk microbiome is still poorly understood. The aim of our study was to assess the impact of mode of delivery on the microbiome composition and diversity present in breast milk of healthy...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001397
更新日期:2016-02-01 00:00:00
abstract::A developmental approach to public health focuses attention on better nourishing girls and young women, especially those of low socio-economic status, to improve mothers' nutrition and thereby the health of future generations. There have been significant advances in the behavioural sciences that may allow us to unders...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章,评审
doi:10.1017/S2040174415001312
更新日期:2015-10-01 00:00:00
abstract::The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of pe...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章,评审
doi:10.1017/S2040174415001105
更新日期:2015-10-01 00:00:00
abstract::Predisposition to offspring metabolic dysfunction due to poor maternal nutrition differs with the developmental stage at exposure. Post-weaning nutrition also influences offspring phenotype in either adverse or beneficial ways. We studied a well-established rat maternal protein-restriction model to determine whether p...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001051
更新日期:2015-08-01 00:00:00
abstract::The aim of this study was to observe the association between maternal undernutrition and metabolic risk indicators in newborns at birth. Fifty-nine expectant mothers between 28 and 40 weeks of gestation were included after obtaining their informed consent. Mothers were divided into undernourished, normally nourished a...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001142
更新日期:2015-08-01 00:00:00
abstract::This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001117
更新日期:2015-08-01 00:00:00
abstract::Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferenti...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章,评审
doi:10.1017/S204017441500015X
更新日期:2015-06-01 00:00:00
abstract::The principles embodied by the Developmental Origins of Health and Disease (DOHaD) view of 'life history' trajectory are increasingly underpinned by biological data arising from molecular-based epigenomic and transcriptomic studies. Although a number of 'omic' platforms are now routinely and widely used in biology and...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000476
更新日期:2015-02-01 00:00:00
abstract::Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol leve...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000312
更新日期:2014-10-01 00:00:00
abstract::The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently hig...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000361
更新日期:2014-10-01 00:00:00
abstract::Adverse uterine environments caused by maternal stress (such as bacterial endotoxin) can alter programming of the fetal hypothalamic-pituitary-adrenal axis (HPAA) rendering offspring susceptible to various adulthood diseases. Thus, protection against this type of stress may be critical for ensuring offspring health. T...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000191
更新日期:2014-06-01 00:00:00
abstract::Although numerous studies have been conducted to examine the causal factors of childhood obesity, the implications of intrauterine oxidative stress on early postnatal adiposity development remain to be elucidated. The Universiti Sains Malaysia Birth Cohort Study aimed to investigate the effects of prenatal oxidative s...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441300055X
更新日期:2014-04-01 00:00:00
abstract::Here we analyze the outcomes of unlimited access to a low-energy (LE) diet in dams and their offspring. At 3 weeks' gestation, pregnant Wistar rats were divided into two groups: (1) the control group received a normoenergetic diet; and (2) the experimental group received the LE diet. In dams, lactation outcomes, food ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000482
更新日期:2014-02-01 00:00:00
abstract::Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000287
更新日期:2013-12-01 00:00:00
abstract::Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression. We aimed to determine whether maternal vitamin D deficiency upregulates fetal renal renin expression, and if this is sustained. We also examined growth and the long-term renal effects in offspring on a n...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000342
更新日期:2013-10-01 00:00:00
abstract::Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000329
更新日期:2013-10-01 00:00:00
abstract::Associations between maternal salivary testosterone at 36 weeks' gestation with birth weight and infant weight gain through 6 months of age were examined in a group of 49 healthy, pregnant women and their offspring. The diurnal decline of maternal testosterone was conserved in late pregnancy, and levels showed signifi...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000135
更新日期:2013-08-01 00:00:00
abstract::Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000736
更新日期:2013-06-01 00:00:00
abstract::The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000724
更新日期:2013-04-01 00:00:00
abstract::The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures in utero and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previou...
journal_title:Journal of developmental origins of health and disease
pub_type: 历史文章,杂志文章
doi:10.1017/S2040174412000517
更新日期:2013-02-01 00:00:00
abstract::A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000505
更新日期:2012-12-01 00:00:00
abstract::Maternal protein restriction (MPR) during pregnancy impaired the reproduction of male offspring. We investigated, during the first wave of spermatogenesis, whether MPR exerts deleterious effects on germ cell proliferation and differentiation, as well as androgen receptor (AR) protein expression, which was used as a ma...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000360
更新日期:2012-10-01 00:00:00
abstract::Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000013
更新日期:2012-08-01 00:00:00
abstract::Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/s2040174412000104
更新日期:2012-06-01 00:00:00
abstract::Adipose tissue (AT) dysfunction links obesity of any cause with cardiometabolic disease, but whether early-life nutritional deficiency can program adipocyte dysfunction independently of obesity is untested. In 3-5-month-old juvenile microswine offspring exposed to isocaloric perinatal maternal protein restriction (MPR...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000232
更新日期:2012-06-01 00:00:00
abstract::Antenatal exposure of the fetus to inflammation may alter postnatal organ development. In our previous work, we demonstrated that the fetal liver is involved in the systemic inflammation associated with chorioamnionitis, leading to metabolic changes. On the basis of these findings, we hypothesized that chorioamnioniti...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000049
更新日期:2012-04-01 00:00:00
abstract::Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering w...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441100064X
更新日期:2012-02-01 00:00:00
abstract::Tobacco smoke has both carcinogenic effects and anti-estrogenic properties and its inconsistent association with breast cancer risk in observational studies may be because of these competing effects across the lifecourse. We conducted a prospective study of prenatal smoke exposure, childhood household smoke exposure, ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174411000614
更新日期:2011-12-01 00:00:00
abstract::The objectives of this study were to describe the prevalence of cigarette use and water pipe smoking in Jordanian university students and to analyze differences in determinants between cigarette smokers and non-smokers. A cross-sectional questionnaire was administered to a random sample of 400 students (18-24 years, 5...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174411000122
更新日期:2011-06-01 00:00:00
abstract::The hypothesis that vitamin content of the diet during gestation alters macronutrient choice, food intake and the expression of serotonin receptors and proopiomelanocortin (POMC) in the hypothalamus of the offspring was investigated. Pregnant Wistar rats (n = 10/group) were fed the AIN-93G diet containing a multivitam...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174410000565
更新日期:2010-12-01 00:00:00
abstract::Rates of weight gain in infancy and early childhood can influence later neurocognitive, metabolic and cardiovascular health. We studied the relationship of weight gain during infancy and early childhood to intelligence quotient (IQ), blood pressure (BP) and body mass index (BMI) at age 9 in children born with very low...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174410000401
更新日期:2010-10-01 00:00:00
abstract::An appropriate foetal cardiovascular (CV) response to reduced substrate supply (e.g. oxygen or other nutrients) is vital for growth and development, and may impact on CV control. The prevailing nutritional environment and associated CV changes may influence subsequent CV responses to challenges during late gestation, ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017440999016X
更新日期:2010-02-01 00:00:00